Desmoid Tumor
Conditions
Interventions
Treatment Group:High-intensity Focused Ultrasound Ablation (HIFUa)
Sponsors
Chongqing Haifu Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Patients with a pathologically confirmed diagnosis of DT by thick needle puncture or surgical resection; (2) patients with symptomatic DTs, or patients with asymptomatic DTs with progression after active surveillance or conservative therapy, or patients with recurrent DTs after surgical resection and strong treatment requirements; (3) patients with tumors that could be visualized on ultrasound; and (4) patients with a tumor depth greater than 1.5 cm from the skin surface.
Exclusion criteria
Exclusion criteria: (1) The total cumulative dose of radiotherapy exceeded 45 Gy, or local skin in the acoustic pathway had become hard and fibrous due to previous radiotherapy; (2) the presence of extensive scars (>1.5 cm in width, >1.0 cm in height from skin) with obvious acoustic attenuation in the acoustic pathway; (3) ruptured skin and soft tissues in the tumor region, unhealed defects and local infection; (4) DTs with important nerve wrapping; (5) patients who were unable to maintain the treatment position for 1 hour; (6) patients with diseases of vital organs; (7) patients allergic to imaging contrast agents; (8) patients with contraindications for sedation and analgesia; and (9) pregnant and lactating patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Non-perfused Volume Rate (NPVR);Progression-free Survival (PFS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of Tumor Ablation;Complete Response (CR);Partial Response (PR);Stable Disease (SD);Progressive Disease (PD); | — |
Countries
China
Contacts
Public ContactWen-Zhi Chen
State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University
Outcome results
None listed