Osteoarthritis
Conditions
Interventions
case series:Nil
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Diseases: osteoarthritis of various causes; 2. Aged between 15 and 55 years, regardless of gender; 3. Defect area: 2-12cm2; 4. The defect depth: Outerbridge III/IV level; 5. Cartilage defect has received other treatments, but the symptoms have not improved or recurred; 6. If osteoarthritis is caused by the change of the joint force line, the joint deformity must be corrected at the same time to restore the normal force line; 7. Patients can adhere to strict postoperative rehabilitation procedures; 8. I or my legal representative have voluntarily accepted this treatment and have signed the Informed Consent; 9. Ability to cooperate in observation of efficacy and adverse events; 10. Women of childbearing age have negative pregnancy tests and agree to use effective contraception during the study period.
Exclusion criteria
Exclusion criteria: 1. BMI >35 [bmi = weight divided by height squared =kg/m2]; 2. X or O legs; 3. Have a history of severe drug allergy or allergic constitution; 4. Women during pregnancy or lactation; men and women during pregnancy; 5. Traditional Chinese medicine containing anti-inflammatory drugs was used for treatment within 2 weeks before the test; 6. Participate in other clinical trials within 1 month before the trial; 7. Patients who received other joint operations within 2 months before the trial; 8. Besides KOA and other joint disease complications, such as: joint local infection, systemic or rheumatoid arthritis, rickets, calcinosis articular cartilage disease, hemochromatosis, inflammatory arthritis, femoral head necrosis, Paget's disease (Paget 's diseases), hemophilia joint disease, infectious arthritis, Charcot arthropathy (Charcot' s diseases) fluff nodular synovitis, synovium cartilage tumour disease; 9. HIV antibody positive, hepatitis virus antibody positive, syphilis and other infectious diseases; 10. Have uncontrollable cardiovascular, kidney, liver, endocrine and other systemic diseases, such as diabetes; 11. Having a known or suspected malignant tumor; 12. A recent history of alcohol and drug abuse, or use of illicit drug therapy; 13. Other pathological, physiological or environmental conditions make it inconvenient for patients to participate in this study; 14. Patients who cannot strictly adhere to postoperative rehabilitation training; 15. The subject may be unable to complete the study due to other reasons, or the researcher considers it inappropriate to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Repair effect of cartilage defect (Cell and animal experiments); | — |
Countries
China
Contacts
Public ContactXu Xiao
Shenzhen Second People's Hospital
Outcome results
None listed