Cerebral aneurysms
Conditions
Interventions
Part I (Single arm design): Remimazolam Group:The dose of besylate remimazolam was adjusted up and down according to the changes of MAP and HR.
Part II (RCT design): Group R and Group P:Group R: Remimazolam induction dose-0.3mg/kg, maintenance dose-2mg/kg/h, at the end of surgery remimazolam dose was adjusted to ED95 dose obtained from part
Sponsors
Shanxi Bethune hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. According to the history, clinical manifestations and imaging examination, the patients with intracranial aneurysms were definitely diagnosed; 2. Patients who are going to be treated with interventional embolization of intracranial aneurysms; 3. Patients aged from 18 to 65 years old; 4. Patients with anesthesia grade I ~ II of American Society of anesthesiologists (ASA).
Exclusion criteria
Exclusion criteria: 1. Patients with predicted difficult airway (cervical spondylosis, Mallampati grade III / IV, mouth opening less than 3 fingers, body mass index > 30kg / m2, etc.); 2. Patients with severe cardiopulmonary insufficiency and coagulation dysfunction; 3. Patients with chronic bronchitis, asthma, history of upper respiratory tract infection or other respiratory diseases in recent one month; 4. Patients who were converted to intracranial aneurysm clipping during operation; 5. Patients with neuropsychiatric disorders who can not cooperate; 6. Patients with previous allergy to embolic and contrast agents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure;heart rate;Incidence of cerebral vasospasm; | — |
Secondary
| Measure | Time frame |
|---|---|
| bucking score;quality of recovery score;Incidence of hypotension;NIH Stroke Scale;levels of MMP-9;levels of NSE;levels of S100ß; | — |
Countries
China
Contacts
Public ContactHan Chongfang
Shanxi Bethune Hospital
Outcome results
None listed