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The clinical study of gemcitabine combined with cisplatin 4 courses of induction chemotherapy + radiotherapy plus 6-cycle tegeor adjuvant chemotherapy in the treatment of n3m0 NPC patients with single arm phase II

The clinical study of gemcitabine combined with cisplatin 4 courses of induction chemotherapy + radiotherapy plus 6-cycle tegeor adjuvant chemotherapy in the treatment of n3m0 NPC patients with single arm phase II

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100041804
Enrollment
Unknown
Registered
2021-01-06
Start date
2021-01-05
Completion date
Unknown
Last updated
2021-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nasopharyngeal carcinoma

Interventions

None listed

Sponsors

Min Huang
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients with newly diagnosed and confirmed non metastatic nasopharyngeal squamous cell carcinoma, who type II-III, N3 (staging, 2017, 8th Edition), received intensity modulated radiation therapy. 1. Patients aged between 18 and 70 are male and female. 2.ECOG0-1 3. Patients whose functions of important organs meet the following requirements: (1) The number of neutrophils > 1.5 * 10^9 / L, hemoglobin > 90g / L, Platelets > 90 * 10^9 / L; (2) Normal liver and kidney function: ast, ALT = 50 ml / min. 4. Women of childbearing age were required to use contraception during the study period. 5. The subjects who voluntarily joined the study signed the informed consent form with date before the specific planning steps, cooperated with regular follow-up and were able to comply with the requirements of the study.

Exclusion criteria

Exclusion criteria: 1. Patients with distant metastasis of nasopharyngeal carcinoma. 2. Subjects with PS >= 2. 3. Patients with life-threatening physical condition or other serious diseases at the same time. 4. Pregnant or lactating patients. 5. Patients with a history of other malignancies. Except for cervical carcinoma in situ, cured basal cell carcinoma, bladder surface tumor, or any cured tumor more than 3 years after study enrollment. 6. Patients who refused to participate.

Design outcomes

Primary

MeasureTime frame
DMFS (distant metatasis-free survival);

Countries

China

Contacts

Public ContactMin Huang

Jiangxi Cancer Hospital

112275557@qq.com+86 13970907500

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026