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The effectiveness of low-dose e-ketamine in preventing shivering after spinal anesthesia in patients with cesarean section

The effectiveness of low-dose e-ketamine in preventing shivering after spinal anesthesia in patients with cesarean section

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100041787
Enrollment
Unknown
Registered
2021-01-05
Start date
2021-01-11
Completion date
Unknown
Last updated
2021-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

shivering

Interventions

control group:placebo (3ml normal saline iv)
experimental group (S1 group):0.2mg/kg e-katamine iv
experimental group (S2 group):0.5mg/kg e-katamine iv

Sponsors

Tianjin Fourth Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
21 Years to 43 Years

Inclusion criteria

Inclusion criteria: 1. The age ranged from 21 to 43 years old; 2. ASA grade I or II; 3. Patients undergoing emergency or elective cesarean section under spinal anesthesia or combined spinal epidural anesthesia.

Exclusion criteria

Exclusion criteria: 1. Patients with liver dysfunction; 2. Patients with renal dysfunction; 3. Patients with uncontrolled severe hypertension, pregnancy induced hypertension, unstable angina pectoris, hyperthyroidism or hypothyroidism; 4. Patients with severe respiratory insufficiency; 5. Patients with severe cardiovascular disease; 6. Intracranial hypertension, central nervous system injury or disease, history of mental disorders, etc.; 7. Patients with basal body temperature < 36 degrees C or higher than 37.2 degrees C; 8. Patients who need blood transfusion during operation; 9. History of long-term sedative and analgesic medication and allergy; 10. Patients with preoperative drug addiction; 11. Patients allergic to any of the drugs used in the study; Patients with any of the above conditions should be excluded from this study.

Design outcomes

Primary

MeasureTime frame
height;weight;education level;Occupation;BMI;Heart rate;Blood preasure;SpO2;Axillary temperature;shivering;

Secondary

MeasureTime frame
VAS scores;sedation scores;increased secretion;respiratory depression;nausea and vomiting (PONV);nystagmus;dizziness;body movement;hallucination;age;Duration of spinal anesthesia;Intraoperative blood loss;Intraoperative lavage fluid volume;Apgar score;cases of hypotension;cases of hypertension;Cases of tachycardia;Cases of bradycardia;Depression rating scale;Anxiety rating scale;Dosage of ropivacaine;

Countries

China

Contacts

Public ContactDefang Xu

Tianjin Fourth Central Hospital

10772378@qq.com+86 22-26249236

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026