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Effect of Early Postoperative Botulinum Toxin Type A Injection Dose on Surgical Scar Appearance: a Prospective, Split-Scar, Randomized Controlled Trial

Effect of Early Postoperative Botulinum Toxin Type A Injection Dose on Surgical Scar Appearance

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100041766
Enrollment
Unknown
Registered
2021-01-05
Start date
2019-06-01
Completion date
Unknown
Last updated
2021-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Scar

Interventions

High-dose group:Immediately after the operation, it was divided into two parts with the midpoint of the suture mouth as the boundary, and the side of the high-dose injection (8U/point) was determined
Low-dose group:Immediately after the operation, it was divided into two parts with the midpoint of the suture mouth as the boundary, and the side of the low-dose injection (4U/point) was determined ac

Sponsors

The First Affiliated Hospital of Zhengzhou University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. The type of incision is a type I surgical incision, and all have plastic and cosmetic sutures. The length of the postoperative scar on the body surface is > 3cm; 2. Aged 16-60 years; 3. No other adjuvant treatments such as radiotherapy or pressure therapy have been received at the surgical incision; 4. Have not received various forms of BTxA treatment in the past; 5. Sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with a history of chronic system diseases such as diabetes and cardiovascular disease; 2. Patients with scar constitution; 3. Patients with malignant tumors; 4. Serious systemic diseases; 5. Pregnant or lactating women; 6. Those who cannot tolerate surgery; 7. Other patients with contraindications to botulinum toxin type A for injection; 8. Other situations deemed inappropriate for selection.

Design outcomes

Primary

MeasureTime frame
the modified Stony Brook Scar Evaluation Scale;the Visual Analogue Scale;

Countries

China

Contacts

Public ContactGuangshuai Li

Department of Plastic and Reconstructive Surgery ,The First Affiliated Hospital of Zhengzhou University

liguangshuai@zzu.edu.cn+86 13838062386

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026