HPV Infection, Uterine Cervical Neoplasms, Sexual Transmitted Diseases
Conditions
Interventions
HPV group vs non-HPV group:Nil
group according to the degree of lesion:Nil
Sponsors
Zhujiang Hospital, Southern Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Female of childbearing age conducting HPV screening from both outpatient department of gynecology and health examination center in each research center; 2. Having an experience of sexual intercourse as well as not during the menstrual period; 3. No sexual intercourse and vaginal medication and flushing 3 days before sampling.
Exclusion criteria
Exclusion criteria: 1. Within 8 weeks of pregnancy of postpartum; 2. Previous history of reproductive tract tumors; 3. Previous history HPV bivalent, tetravalent or nine-valent vaccination; 4. Received treatment for anti- HPV and STDs pathogens infection; 5. Previous history of hysterectomy, cervical surgery and pelvic radiotherapy; 6. Utilization of broad-spectrum antibiotics, probiotics or vaginal suppositories in reproductive tract within 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 16S rRNA gene sequencing of vaginal secretions;Genotyping of HPV;ThinPrep cytology test;cervical secretions 16s rRNA gene sequencing; | — |
Secondary
| Measure | Time frame |
|---|---|
| Microbiological assessment of vaginal secretions;STDs pathogens DNA test; | — |
Countries
China
Contacts
Public ContactHongwei Zhou
Zhujiang Hospital of Southern Medical University
Outcome results
None listed