Comparative study of sacubitril valsartan and valsartan in patients of mid-range ejection fraction with ventricular aneurysm after myocardial infarction.

Comparative study of sacubitril valsartan and valsartan in patients with ventricular aneurysm

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100041700

Enrollment

Unknown

Registered

2021-01-01

Start date

2021-01-10

Completion date

Unknown

Last updated

2021-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

left ventricular aneurysm after myocardial infarction

Interventions

sacubitril valsartan:sacubitril valsartan

valsartan:valsartan

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Patients of novel acute anterior wall myocardial infarction within the past 6 months, diagnosed with ventricular aneurysm by two or more echocardiographic physicians. 2.40% < LVEF < 50%. 3.Aged of 18-80 years.

Exclusion criteria

Exclusion criteria: 1. Scr > 200µmol/L or eGFR < 30ml/min·1.73 m2, bilateral renal artery stenosis, hyperkalemia, history of vascular neuroedema, pregnant or lactating women, contraindications such as allegry to ARNI or ARB etc. 2. Systolic pressure lower than 100 mmHg, or occurence of hypotension related symptoms after low dose ARNI or ARB applied. 3. Malignant neoplasms, severe liver and kidney failure, severe anemia or any cause that leads to a life expectancy of less than 12 months. 4. Disagreement of participation or being involved in other clinical studies.

Design outcomes

Primary

Measure	Time frame
Cardiac ultrasound;Cardiac magnetic resonance;	—

Countries

China

Contacts

Public ContactGuoming Zhang

Xiamen Cardiovascular Hospital, Xiamen University

guomingheart@126.com+86 15160716526

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026