Skip to content

Evaluation of disease status and epigenetic study of endemic cretinism in historical severe iodine deficiency disorders area

Evaluation of disease status and epigenetic study of endemic cretinism in historical severe iodine deficiency disorders area

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100041696
Enrollment
Unknown
Registered
2021-01-01
Start date
2021-01-28
Completion date
Unknown
Last updated
2021-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Iodine deficiency disorders

Interventions

case series:Nil

Sponsors

Centre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, China
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Prerequisites for patients with endemic cretinism: patients with endemic cretinism live in iodine-deficient areas; at the same time, they have different degrees of mental retardation, mainly manifested by different degrees of mental retardation. Auxiliary conditions: different degrees of hearing, speech and motor nerve disorders; hypothyroidism, different degrees of physical development disorders, cretinism images (stupid, wide face, wide eye distance, collapsed nose, abdominal bulge, etc.); Different degrees of hypothyroidism (dry skin and hair, X-ray bone age and delayed epiphyseal healing, decreased plasma PBI, increased serum T4, TSH).

Exclusion criteria

Exclusion criteria: Exclude those with a history of childbirth injuries, encephalitis, meningitis and drug poisoning.

Design outcomes

Primary

MeasureTime frame
thyroid function;

Countries

China

Contacts

Public ContactHongmei Shen

Chinese Center for Disease Control and Prevention

shenhm119@hrbmu.edu.cn+86 13633637369

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026