hysteroscopy
Conditions
Interventions
A:The initial loading dose of remimazolam besylate was 7mg
B:The initial loading dose of remimazolam besylate was 9.5mg
C:The initial loading dose of remimazolam besylate was 12mg
D:The initial loading dose of remimazolam besylate was 14.5mg
Sponsors
Shenzhen Maternity and Child Healthcare Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective hysteroscopic surgery (level 1-2 surgery); 2. BMI: 20 to 25 kg/m2; 3. ASA I - II; 4. Agree to participate in this study.
Exclusion criteria
Exclusion criteria: 1.Benzodiazepines or opioids are taken daily or intermittently for the last 1 month or 3 months; 2.Pregnancy or lactation;Patients with obvious respiratory and circulatory dysfunction, abnormal blood routine, blood 3.biochemistry and blood coagulation function preoperative; 4.Patients with severe neuropsychiatric disease; 5.Allergic or contraindicated to benzodiazepines, opioids, flumazine, naloxone and other drugs and their components; 6.Patients with myasthenia gravis; 7.Patients with modified Mallampati score >= III or with other respiratory management difficulties.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate of subjects with MOAA/S score <= 3 points after giving the first trial drug; | — |
Secondary
| Measure | Time frame |
|---|---|
| MOAA/S score of subjects at each observation time point;The time begin the operation after the first trial drug was given ;The frequency and dose of remimazolam besylate were added;Adverse event occurrence;if injection pain happen;The time from the end of the last dose until the human subject wakes up;The time from the end of the last administration until the human subject meets the criteria for withdrawal;The situation and dose of flumazine; | — |
Countries
China
Contacts
Public ContactDaili Chen
Shenzhen Maternity and Child Healthcare Hospital
Outcome results
None listed