Effect of accurate multimodal analgesia on postoperative analgesia and quality of life in patients undergoing video-assisted thoracoscopic surgery

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100041682

Enrollment

Unknown

Registered

2021-01-01

Start date

2021-01-01

Completion date

Unknown

Last updated

2021-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative analgesia

Interventions

Patient-controlled intravenous analgesia group:Spray tazoxin 60mg + dexamethasone 5mg + tropisetron hydrochloride for injection 10 mg+ normal saline, total 100mL

Plane block group of serratus anterior muscle guided by PCA combined with ultrasound:On the basis of patient-controlled intravenous analgesia, anterior serratus muscle block was performed with 0.375%

PCA combined with incision infiltration block:On the basis of patient-controlled intravenous analgesia, combined with 0.5% ropivacaine local incision infiltration

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Patients >= 18 years old who underwent video-assisted thoracoscopic surgery for the first time. (2) willing to participate in this study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: (1) Patients with hearing and visual impairment, severe cognitive impairment or mental illness. (2) patients with disease recurrence or reoperation during the follow-up period. (3) patients with acute myocardial infarction, cardiac arrest or severe shock during perioperative period. (4) those who are unable to cooperate with follow-up or have poor compliance. (5) the researchers believe that there are any factors that affect the results of the test.

Design outcomes

Primary

Measure	Time frame
SF- 12 scale was used to evaluate the quality of life of patients at 48 and 72 hours after operation.;NRS pain score scale was used to evaluate the pain of patients at 1 h, 3 h, 12 h, 24 h and 48 h after operation;	—

Secondary

Measure	Time frame
The postoperative inflammatory response was evaluated by measuring the levels of serum C-reactive protein (CRP) and interleukin-6 (IL-6) 1 day after operation;The cellular immune function of patients was evaluated by measuring the levels of CD3+, CD4+, CD8+, CD4+/CD8+ and natural killer cells on the 1st, 3rd and 5th day after operation;	—

Countries

China

Contacts

Public ContactJiru Zhang

Affiliated Hospital of Jiangnan University

zjr2010508@126.com+86 15852512299

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026