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Effects of Prophylactic Antibiotic Administration and Antibiotic Timing on Culture Results and Clinical Outcomes of Pediatric Musculoskeletal Infection: a Protocol for a Randomized, Controlled, Clinical Trial

Effects of Prophylactic Antibiotic Administration and Antibiotic Timing on Culture Results and Clinical Outcomes of Pediatric Musculoskeletal Infection: a Protocol for a Randomized, Controlled, Clinical Trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100041631
Enrollment
Unknown
Registered
2021-01-01
Start date
2021-06-01
Completion date
Unknown
Last updated
2021-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pediatric Musculoskeletal Infection

Interventions

A:antibiotics 1 week prior to culture collecting
B: antibiotics 3 days prior to culture collecting
C:antibiotics 1 day prior to culture collecting
D:antibiotics 1 day after culture collecting

Sponsors

Shenzhen Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 18 Years

Inclusion criteria

Inclusion criteria: (1) Children and adolescents with a diagnosis of MSI; (2) Aged 0-18 years; (3) In agreement to participate in the clinical study.

Exclusion criteria

Exclusion criteria: (1) Patients with evidence of current infections such as chronic recurrent multifocal osteomyelitis, poststreptococcal disease, necrotizing fasciitis, cellulitis or other fungal or mycobacterial infections. (2) Patients who have recently (within 4 weeks) received any antibiotic treatment no matter related or unrelated to the MSIs.

Design outcomes

Primary

MeasureTime frame
culture positivity;

Secondary

MeasureTime frame
blood cell count;C-reactive protein;white erythrocyte sedimentation rate;Length of hospital stay;

Countries

China

Contacts

Public ContactChao You

Shenzhen Children's Hospital

youchao1978@sina.com+86 18938690627

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 12, 2026