Evaluation of the Effectiveness of MRI Combined with Nasopharyngeal Fiberscopy in Screening for Nasopharyngeal Carcinoma: a Multicenter Randomized Controlled Trial

Optimization and Evaluation of a New Screening Program for Nasopharyngeal Carcinoma: a Randomized Controlled Screening Trial

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100041628

Enrollment

Unknown

Registered

2021-01-01

Start date

2021-01-01

Completion date

Unknown

Last updated

2023-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nasopharyngeal carcinoma

Interventions

the new screening strategy group:MRI plus nasopharyngeal endoscopy examination

the control group:nasopharyngeal endoscopy examination

Eligibility

Sex/Gender

All

Age

30 Years to 69 Years

Inclusion criteria

Inclusion criteria: 1. Residents in Zhongshan, Jiangmen, Sihui and Wuzhou city, Shunde district and Cangwu county; 2. Have no case history of nasopharyngeal carcinoma; 3. ECOG 0-2; 4. Should subscribe informed consents.

Exclusion criteria

Exclusion criteria: 1. Have severe cardiovascular, brain, liver, lung or kidney disease; 2. Have autoimmune disease; 3. Currently receiving glucocorticoids or immunosuppressive therapy; 4. In poor mental state or unclear consciousness.

Design outcomes

Primary

Measure	Time frame
the detection rate of NPC;	—

Secondary

Measure	Time frame
the early diagnosis rate of NPC;the positive predictive value of diagnostic methods for NPC;the sensitivity of diagnostic methods for NPC;the specificity of diagnostic methods for NPC;cost-effectiveness ratio;incremental cost effectiveness ratio;the survival rate of nasopharyngeal carcinoma patients;the compliance rate of screening participants;the sensitivity of triage methods in serology high-risk participant;the specificity of triage methods in serology high-risk participant;the positive predictive value of triage methods in serology high-risk participant;the negative predictive value of triage methods in serology high-risk participant;	—

Measure

Time frame

the early diagnosis rate of NPC;the positive predictive value of diagnostic methods for NPC;the sensitivity of diagnostic methods for NPC;the specificity of diagnostic methods for NPC;cost-effectiveness ratio;incremental cost effectiveness ratio;the survival rate of nasopharyngeal carcinoma patients;the compliance rate of screening participants;the sensitivity of triage methods in serology high-risk participant;the specificity of triage methods in serology high-risk participant;the positive predictive value of triage methods in serology high-risk participant;the negative predictive value of triage methods in serology high-risk participant;

—

Countries

China

Contacts

Public ContactCao Sumei

Sun Yat-Sen University Cancer Center

caosm@sysucc.org.cn+86 20 8734 5682

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 5, 2026