Alzheimer's disease
Conditions
Interventions
HF-rTMS:HF-rTMS
LF-rTMS:LF-rTMS
Sponsors
The First Affiliated Hospital of Shantou University Medical College
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. The age ranged from 50 to 85 years old; 2. The patients with Alzheimer's disease who were diagnosed after screening in a regular Grade-A hospital system had not received transcranial magnetic stimulation, transcortical electrical stimulation, deep brain electrical stimulation, vagus nerve electrical stimulation and other treatments in the past; Or 3. memory and cognitive function decreased in recent one year, MMSE OR MoCa score was 11-26 (more than 6 years of Education) or 11-22 (less than 6 years of Education); MRI showed medial temporal atrophy (hippocampus, entorhinal cortex, amygdala), MTA visual evaluation scale >= 2; or PET-CT showed decreased FDG absorption in medial temporal lobe.
Exclusion criteria
Exclusion criteria: 1. There is a history of severe brain organic lesions or brain surgery, such as brain space occupying, hydrocephalus, intracranial hematoma, etc.; 2. There are serious complications, such as frequent seizures, brain tumor surgery, intracranial infection, serious heart disease, lung disease, mania, severe mental disorders, etc.; 3. The implanted pacemaker, defibrillator, cochlear implant or other nerve stimulator, or the implanted steel plate and other materials cannot cooperate with the completion of transcranial magnetic stimulation therapy and magnetic resonance imaging; 4. Frontotemporal dementia, vascular dementia, Lewy body dementia and other diseases; 5. White matter lesions with Fazekas score > 3 or cerebral infarction in medial temporal lobe were excluded 6. In severe hydrocephalus, Evans index was greater than 0.33, frontal horn became sharp < 100; 7. Ohters referred to the NINCDS-ADRDA exclusion criteria (revised - 2007).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-mental state examination (MMSE); | — |
Secondary
| Measure | Time frame |
|---|---|
| AD Assessment Scale-cognitive subscale (ADAS-cog);Generalized anxiety disorder scale;activities of daily living scale (ADL);Center for Epidemiological Studies Depression Scale;Montreal Cognitive Assessment (MOCA); | — |
Countries
China
Contacts
Public ContactJian Chen
The First Affiliated Hospital of Shantou University Medical College
Outcome results
None listed