Total knee replacement
Conditions
Interventions
placebo group:placebo 350mg
celecoxib:celecoxib 200mg
pregabalin group:pregabalin 150mg
Joint Group:Celecoxib 200mg+ Pregabalin 150mg
Sponsors
The Third Affiliated Hospital of Zunyi Medical University
Eligibility
Sex/Gender
All
Age
46 Years to 72 Years
Inclusion criteria
Inclusion criteria: 1. Patients over 50 years old and under 80 years old will undergo elective, primary, unilateral total knee arthroplasty; 2. Patients with ASA physical condition below grade 3 of American Society of anesthesiologists; 3. Patients who are willing to participate in this study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with history of liver and kidney insufficiency, severe cardiopulmonary disease, severe digestive tract disease and psychosis; 2. Patients allergic to celecoxib and pregabalin; 3. Patients who had taken celecoxib and pregabalin within one week before operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS??;Cumulative dosage of opioid receptors; | — |
Countries
China
Contacts
Public ContactXiang Bingyan
The Third Affiliated Hospital of Zunyi Medical University (Zunyi First People's Hospital)
Outcome results
None listed