Colonoscopy
Conditions
Interventions
R group:Give the initial dose of 5.0 mg of remimazolam. If sufficient sedation is not obtained, inject supplementary doses of remimazolam (2.5 mg per dose), and the supplement interval must be more th
P group:Give the initial dose of 1.5 mg/kg of propofol. If sufficient sedation is not obtained, inject supplementary doses of propofol (0.5mg/kg per dose), and the supplement interval must be more tha
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Scheduled to undergo a colonoscopy; 2.Aged 18~60 years; 3.American Society of Anesthesiologists (ASA) physical status classification system risk class I~II; 4.Body mass index (BMI)< 35 kg/m2; 5.Patient was voluntary to participate in the trial and signed the informed consents, and willing to comply with study requirements.
Exclusion criteria
Exclusion criteria: 1.About to receive endotracheal intubation or laryngeal mask; 2.Required complex endoscope procedures (such as endoscopic submucosal dissection, transoral endoscopic myotomy, etc.); 3.Patients with psychiatric disorders (schizophrenia, mania, bipolar disorder, mental disorder, etc.), a long history of use of psychotropic drugs, and cognitive dysfunction. 4.History of drug abuse, and alcohol abuse within the 2 years before screening stage (alcohol abuse: average daily consumption of more than 2 single units of alcohol (1 unit =360 mL beer or 45 mL 40% liquor or 150 mL wine)); 5.Use of benzodiazepines and/or opioids for nearly three months; 6.Allergy or contraindication to benzodiazepines, opioids, propofol and their components; 7.Unable to understand the scale of recovery quality, and difficult to complete the survey of recovery quality.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative quality of recovery scale;incidence of adverse events (hypotension, respiratory depression, pain at the injection site);Patient satisfaction;Endoscopic doctor satisfaction;Anesthesia induction time;awake time; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative quality of recovery scale;sedation success rate; | — |
Countries
China
Contacts
Public ContactDunyi Qi
Xuzhou Medical University
Outcome results
None listed