advenocortical function inhibition
Conditions
Interventions
Sponsors
The Second Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Patients must meet all of the following criteria for inclusion in this study: 1. Aged 18-90 years, gender unlimited; 2. ASA range from I to III grade; 3. 18 kg/m2<BMI<30kg/m2; 4. Clear understanding and voluntary participation in this study.
Exclusion criteria
Exclusion criteria: 1. Patients with endocrine system diseases such as Kuxing syndrome, pituitary adenoma and adrenal tumor; 2. Patients with hormone drugs within 3 months before operation; 3. Patients with glucocorticoid drugs intraoperatively and postoperatively; 4. Asthma patients; 5. Severe respiratory diseases (obstructive sleep apnea syndrome, acute respiratory infection, acute attack of chronic obstructive pulmonary disease, uncontrolled asthma, active massive hemoptysis, severe pulmonary hypertension, etc); 6. Acute heart failure; unstable angina pectoris; myocardial infarction within 6 months before screening; resting electrocardiogram heart rate = 450 ms, female >= 470ms; patients with aortic aneurysm; 7. Infectious heart diseases such as myocarditis or endocarditis; septicemia; 8. People with mental system diseases (schizophrenia, mania, bipolar disorder, insanity, etc.) and long-term history of taking psychotropic drugs and cognitive impairment; 9. Anemia or thrombocytopenia: Hb ULN +3s and/or APTT > ULN+10s; 11. Liver dysfunction: AST and/or ALT >= 2.5 x ULN, TBIL >= 1.5 x ULN; 12. Renal dysfunction: urea or urea nitrogen >= 1.5x ULN, serum creatinine greater than the upper limit of normal value; 13. There was a history of substance abuse, drug abuse and alcohol abuse within two years prior to the screening period, with alcohol consumption, i.e. drinking more than 2 units of alcohol per day on average (1 unit =360 ml beer or 45 ml liquor with 40% alcohol or 150 wine); 14. Patients who did not receive regular hypotension or have poor blood pressure control (sitting systolic blood pressure >= 160 mmHg or 90 mmHg, and / or 100 mmHg diastolic blood pressure during screening); 15. Patients whose blood glucose was not satisfactorily controlled (random blood glucose >= 11.1 mmol/l); 16. Allergic or contraindicated drugs such as benzodiazepines, opioids, etomidate, propofol and their components; 17. Patients identified as having difficulties in respiratory management (modified Mallampati ? grade); 18. Participated in any clinical drug trial and used the trial drug as a subject in the last 3 months; 19. Patients who could undergo adrenal surgery; 20. Contraindications of trauma and infection in acupuncture and moxibustion puncture site; 21. Other factors that may interfere with the results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration of Serum cortisol; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of patients' consciousness recovery;Duration of Tracheal tube withdrawal;Duration of staying in PACU;Postoperation nausea and vomitting times;Excessive sedation;POCD;Incidence of fever;Postoperative recovery time of gastrointestinal function;Chalder fatigue rating scaleChiari; | — |
Countries
China
Contacts
Public ContactSiyuan Li
The Second Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed