Lung cancer meningeal metastases
Conditions
Interventions
experimental group:ametinil combined with pemetrexed intrathecal injection
Sponsors
The Second Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The study population consisted of 20-25 patients with histologically confirmed clinical stage IV EGFR positive lung adenocarcinoma; 2. Patients with meningeal metastasis confirmed by CSF cytology after first-line TKI treatment; 3. Patients with ECoG PS score 0-2; 4. Determine the patients without contraindications of chemotherapy and lumbar puncture; 5. Patients whose expected survival time is more than 3 months; 6. Collect the clinical data needed for the study.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications of lumbar puncture; 2. Patients with allergic history of pemetrexed; 3. HIV positive subjects; 4. Patients with autoimmune diseases; 5. Patients with severe infection or severe underlying diseases, such as hemorrhagic peptic ulcer, intestinal obstruction, heart failure, renal failure or poorly controlled diabetes, etc.; 6. Patients who can not comply with the test requirements; 7. Pregnant (confirmed by serum or urine ß - hCG) or lactating subjects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression-free survival;Objective mitigation rate; | — |
Countries
China
Contacts
Public ContactTao Xin
The Second Affiliated Hospital of Harbin Medical University
Outcome results
None listed