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Influence of permissive hypercapnia on postoperative delirium in elderly patients undergoing radical resection of thoracoscopic esophageal carcinoma

Influence of permissive hypercapnia on postoperative delirium in elderly patients undergoing radical resection of thoracoscopic esophageal carcinoma

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000041523
Enrollment
Unknown
Registered
2020-12-27
Start date
2021-01-30
Completion date
Unknown
Last updated
2021-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal carcinoma

Interventions

N group:Arterial PCO2 35-45 MMHG
H group:Arterial PCO2 45-55 MMHG
P group:erial PCO2 55-65 MMHG

Sponsors

The Second Affiliated Hospital of Anhui Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Subjects aged 65-80, regardless of gender; 2. For patients with esophageal cancer diagnosed by pathology or cytology, endoscopic radical resection is planned; 3. Patients with ASA grade II-III; 4. Subjects with life expectancy greater than 3 months; 5. The subjects understand and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Subjects with MMSE score less than 24; 2. Patients with second primary tumor; 3. Patients with severe diseases include severe liver and kidney injury, autoimmune diseases, immunodeficiency, cardiovascular and cerebrovascular diseases, neuropsychiatric diseases, blood diseases, etc.; 4. Patients with previous difficulties in laparoscopic surgery (such as severe chronic obstructive pulmonary disease, acute inflammatory bowel disease, obesity, etc.); 5. Patients with poor control of diabetes and hypertension; 6. Patients with poor compliance are difficult to cooperate with treatment and follow-up; 7. Subjects participating in other clinical studies in the last three months; 8. Other situations that the researcher thinks are not suitable to participate in the study.

Design outcomes

Primary

MeasureTime frame
Postoperative delirium;

Secondary

MeasureTime frame
rSO2;emergence agitation;extubation time';

Countries

China

Contacts

Public ContactXianwen Hu

The Second Affiliated Hospital of Anhui Medical University

huxianwen001@163.com+86 17764433509

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026