transfusion independent aplastic anemia
Conditions
Interventions
experimental group:Cyclosporine combined with danazol
control group:Cyclosporine
Sponsors
Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Aged > 14 years. 2) Aplastic anemia is clearly diagnosed from the peripheral blood smear and bone marrow examination. 3) Transfusion independence with ANC > 0.5 x 10^9/L. 4) Never received immunosuppressive therapy(IST) before or received IST less than 4weeks. 5) Never received androgen therapy before or received androgen therapy less than 4weeks. 6) Can fully understand and voluntarily sign informed consent forms.
Exclusion criteria
Exclusion criteria: 1) Aplastic anemia patients with PNH clones. 2) Diagnosed with congenital aplastic anemia or other congenital bone marrow failure. 3) Patients with abnormal liver function, i.e. ALT or AST > 2.5ULN, or TB > 2ULN, or CrCl < 60 ml/min/1.73 m^2. 4) Experienced a solid tumor or received radiation therapy/chemotherapy. 5) Nursing women. 6) Inability to understand or to follow study procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| superior remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| rate of progression;relapse rate; | — |
Countries
China
Contacts
Public ContactShi Jun
Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
Outcome results
None listed