novel coronavirus pneumonia (COVID-19)
Conditions
Interventions
Two groups:Voluntary vaccination with CoronaVac or Quadrivalent influenza virus vaccine
Sponsors
Jinyun Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University (Jinyun County People's Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Older than 18 years of age; (2) Voluntary vaccination with CoronaVac or Quadrivalent influenza virus vaccine; (3) Signed informed consent form.
Exclusion criteria
Exclusion criteria: (1) Antibody test positive or nucleic acid test positive for novel coronavirus; (2) Nucleic acid test positive for influenza A virus or influenza B virus; (3) Have history of travel or residence in the COVID-19 case reporting community within the past 14 days, history of contact with a COVID-19 confirmed or asymptomatic infected person within the past 14 days, or contact with a patient with fever or respiratory symptoms from the case reporting community within the past 14 days; (4) With clinical presentations associated with COVID-19 or influenza such as upper respiratory symptoms or fever within the past 30 days; (5) Pregnancy, lactation, or prepare to pregnant within the next 1 year; (6) Known allergy to CoronaVac or quadrivalent influenza virus vaccine or who meet any of the contraindications to vaccination in the CoronaVac or quadrivalent influenza virus vaccine instructions; (7) Taking antibiotics, microbiological agents, hormonal drugs or having a history of diarrheal disease or other gastrointestinal disorders within the last 1 months, or having a history of gastrointestinal surgery; (8) Have history of autoimmune diseases, such as systemic lupus erythematosus, nodular disease, autoimmune thrombocytopenic purpura, etc.; (9) Have history of malignancy or significant organ transplantation; (10) Have other diseases that, in the opinion of the investigator, are not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Single-cell RNA-sequencing;Neutralizing antibody detection;16sDNA sequencing or macrogenomic sequencing; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nucleic acid and antibody detection of SARS-CoV-2 or influenza virus;Blood routine, blood biochemistry, CRP;Inflammatory factor testing; | — |
Countries
China
Contacts
Public ContactYimin Zhang
Jinyun Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University (Jinyun County People's Hospital)
Outcome results
None listed