missed miscarriage
Conditions
Interventions
mifepristone group:mifepristone 200mg orally
Letrozol: letrozole 10mg once a day for 3 consecutive days
Sponsors
The University of Hong Kong - Shenzhen Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: All women 18 years of age or older who were diagnosed with unexplained first trimester missed miscarriage were approached for enrolment into the study. Missed miscarriage was diagnosed by the ultrasound finding. Diagnostic criteria for missed miscarriage is the patient had no significant vaginal bleeding and the cervix was still closed. Transvaginal ultrasound shows: pregnancy sac is equal or more than 25mm, no yolk sac, embryo length is equal or more than 7mm no fetal pole. Whose gestational age is between 5 and 12 completed weeks were included in the study. Included the date of the first day of the last menstrual period to calculate gestational age.
Exclusion criteria
Exclusion criteria: Women who had an incomplete or inevitable abortion (defined as the absence of a gestational sac, an open cervical ,or both). A previous attempt to terminate the pregnancy, abnormal uterine lesions such as fibroids or congenital malformations, pregnancy despite an intrauterine contraceptive device (a known cause of miscarriage), medical disorders such as cardiac or hemorrhagic disease. Women who had a contraindication to mifepristone or misoprostol, suspected hydatidiform mole, patients who is breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete abortion rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| side effects;patient satisfaction;the rate of urgent surgical intervention; | — |
Countries
China
Contacts
Public ContactDu Libei
The University of Hong Kong - Shenzhen Hospital
Outcome results
None listed