The efficacy and safety of different dosage and duration of amoxicillin-voronazan dual therapy in Helicobacter pylori eradication: A prospective, randomized, open clinical trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000041477

Enrollment

Unknown

Registered

2020-12-27

Start date

2021-01-01

Completion date

Unknown

Last updated

2021-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori

Interventions

1:Seven days duration: Amoxcillin(1g bid)+ Vonoprazan (20mg bid)

2:Seven days duration: Amoxcillin(1g tid)+ Vonoprazan (20mg bid)

3:Ten days duration: Amoxcillin(1g bid)+ Vonoprazan (20mg bid)

4:Ten days duration: Amoxcillin(1g tid)+ Vonoprazan (20mg bid)

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-65 years; 2. First-line treatment; 3. Hp positive confirmed by RUT or histology; 4. willing to attend the research.

Exclusion criteria

Exclusion criteria: 1. Hp eradication history; 2. History of drug allergy; 3. ZollingerEllison syndrome; 4. gastric cancer, peptic ulcers and upper gastrointestinal bleeding; 5. history of gastrectomy; 6. serious underlying disease; 7. PPI and antibiotics users; 8. pregnancy; 9. HBV patients; 10. refuse to attend the research.

Design outcomes

Primary

Measure	Time frame
eradication rate;	—

Secondary

Measure	Time frame
side effects;	—

Countries

China

Contacts

Public ContactYi Hu

The First Affiliated Hospital of Nanchang University

360041934@qq.com+86 18079140226

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026