diabetic mellitus
Conditions
Interventions
experimental group:Standard treatment and dapagflozin
control group:Standard treatment
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 50 years; 2. The history of diabetic mellitus; 3. NT-proBNP >= 125pg/ml; 4. Willing to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. History of heart disease comorbidities other than hypertension and diabetes caused; 2. ECG abnormalities, including clinically significant ST-T changes, left bundle branch block, arrhythmia, etc.; 3. The abnormalities of the echocardiography, including decreased ejection fraction, abnormal ventricular wall thickness and/or contraction activity, severe valve disease, moderate or higher pulmonary hypertension, and other significant abnormalities; 4. History of malignant tumor; 5. History of chronic infectious diseases; 6. Use hormone therapy for systemic diseases; 7. Severe liver and kidney dysfunction (including renal replacement therapy); 8. Severe cognitive dysfunction or dementia; 9. The life expectancy is less than 1 year; 10. SGLT2 inhibitor and pioglitazone and rosiglitazone are being used.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cardiovascular events; | — |
Secondary
| Measure | Time frame |
|---|---|
| All cause mortality or hospitalization;the unexpected cardiovascular diseases caused hospitalization or death; | — |
Countries
China
Contacts
Public ContactJingmin Zhou
Zhongshan Hospital, Fudan University
Outcome results
None listed