Lung cancer patients with inactive tuberculosis
Conditions
Sponsors
Heilongjiang Infectious Disease Prevention and Control Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Patients with advanced lung cancer confirmed by pathology; 2. Patients with non active pulmonary tuberculosis diagnosed by imaging methods; 3. Patients whose sputum culture results were negative; 4. Patients with measurable tumor lesions (spiral CT scan >= 10 mm, meet RECIST 1.1 standard); 5. Patients with expected survival > 3 months; 6. Age: >= 18 years old, male or female; 7. Patients with ECoG PS: 0-2; 8. The functions of important organs meet the following requirements: (1) Absolute neutrophil count >= 1.5 x 10^9 / L, platelet count >= 100 x 10^9 / L, hemoglobin count >= 9g / dl; (2) Bilirubin 60 ml / min; 9. Women of childbearing age must have a negative pregnancy test (ß hCG) before treatment, and women of childbearing age and men (having sex with women of childbearing age) must agree to use effective contraceptives continuously during treatment and 6 months after the last dose of treatment; 10. The patients who voluntarily joined the study signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with other malignant tumors in the past or at the same time, except the cured basal cell carcinoma of skin and carcinoma in situ of cervix; 2. Patients with uncontrolled, symptomatic brain metastases, uncontrollable psychiatric history, or severe intellectual or cognitive impairment; 3. Patients with active, known or suspected autoimmune diseases, hypothyroidism who only need hormone replacement therapy, and skin diseases (such as vitiligo, psoriasis or alopecia) who do not need systemic treatment can be included; 4. Patients with congestive heart failure, uncontrollable arrhythmia, myocardial infarction within 6 months, unstable angina pectoris, stroke or transient ischemic attack; 5. Patients who can not comply with the trial protocol or cooperate with the follow-up; 6. Patients with history of psychotropic drug abuse, alcoholism or drug abuse; 7. Human immunodeficiency virus (HIV, HIV 1 / 2 antibody) positive patients; 8. Subjects who are considered unsuitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| objective response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease control rate;Progression Free Survival;overall survival;Recovery rate of mycobacterium tuberculosis of sputum culture;safety; | — |
Countries
China
Contacts
Public ContactChunli Wang
Heilongjiang Infectious Disease Prevention and Control Hospital
Outcome results
None listed