functional dyspepsia
Conditions
Interventions
Mild placebo:placebo
Mild low dose:Low dose of BL-99 powder
Mild high dose:high dose BL-99 power
Severe placebo:placebo
Severe low dose:drug and Low dose of BL-99 powder
severe high dose:drug and high dose of BL-99 powder
Sponsors
China Agricultural University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Aged 18-60 years; (2) the Roman IV diagnosis standard: one or more of the following symptoms, namely, postprandial fullness, early enough, epigastric pain, epigastric burning sensation, postprandial nausea or vomiting, belching and bloating gas, acid regurgitation, burning sensation, retrosternal pain or discomfort, such as the course more than 6 months, nearly three months of symptom onset; (3) Willing to provide demographic information (age, weight, height, etc.); (4) Be willing to and complete daily and weekly questionnaires on general health, intestinal function and gastrointestinal symptoms.
Exclusion criteria
Exclusion criteria: (1) Indigestion caused by serious organic lesions; (2) Pregnancy; (3) Smokers and alcoholics; (4) Take any medication for constipation or diarrhea; (5) Currently taking any anti-inflammatory medication regularly; (6) Usually eat fermented foods or probiotics (for example, yogurt containing live cultures or supplements); (7) Received antibiotics in the past three months; (8) A history of clinically significant diarrhea or C. diff infection in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical symptom score;The metagenome of intestinal flora;IL-6;TNF-a; | — |
Secondary
| Measure | Time frame |
|---|---|
| Short Chain Fatty Acids;Pepsinogen I;Pepsinogen II;gastrin;Metabolites in feces; | — |
Countries
China
Contacts
Public ContactWang Ran
College of Food Science and Nutritional Engineering, China Agricultural University
Outcome results
None listed