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The relationship between amniotic inflammatory biomarkers and pregnancy outcome after emergency cervical cerclage

The value of amniotic inflammatory biomarkers in predicting pregnancy outcome after emergency cervical cerclage in cervical insufficiency with cervical dilation patients

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000041409
Enrollment
Unknown
Registered
2020-12-25
Start date
2013-01-01
Completion date
Unknown
Last updated
2021-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical Insufficiency

Interventions

live infant group and dead infant group:Nil

Sponsors

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Subjects aged 18-50 years; 2. Subjects at 16-28 weeks of gestation; 3. Subjects with cervical dilatation >= 1cm; 4. Subjects who underwent ECC within 48 hours after sheep puncture.

Exclusion criteria

Exclusion criteria: 1. Subjects with premature rupture of membranes before emergency cervical cerclage; 2. Subjects with active contractions before emergency cervical cerclage; 3. Subjects with clinical chorioamnionitis before emergency cervical cerclage (maternal body temperature >= 38 degree C, with any of the following: baseline fetal heart rate >= 160 beats / min, maternal peripheral blood WBC >= 15 x 10^9 / L, uterine tenderness or vaginal secretion odor); 4. Subjects who were diagnosed with severe pregnancy complications and internal and external diseases before emergency cervical cerclage; 5. Fetal chromosome abnormality or severe fetal malformation.

Design outcomes

Primary

MeasureTime frame
Amniotic fluid white blood cell;Amniotic fluid TNF-a;Amniotic fluid Interleukin-1ß;Amniotic fluid Interleukin-2 receptor;Amniotic fluid Interleukin-6;Amniotic fluid Interleukin-8;Amniotic fluid Interleukin-10;—

Countries

China

Contacts

Public ContactLiu Yinglin

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

lyl-sharry@163.com+86 13711663380

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026