Schizophrenia
Conditions
Interventions
celecoxib group:Combined celecoxib 200mg/d
control group:placebo
Sponsors
Ethics Committee of the Second Affiliated Hospital of Xinxiang Medical College
Eligibility
Sex/Gender
All
Age
16 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. The subjects who can effectively communicate with researchers and research staff, fill in research related materials, understand the informed consent form, and sign the written informed consent form before any research evaluation; 2. Male or female, hospitalized patients, 55 years old >= 16 years old; 3. Patients diagnosed by two professional psychiatrists as meeting DSM-IV diagnostic criteria for schizophrenia, and PANSS score >= 60; 4. Patients who did not receive long-acting antipsychotics or injections within at least two months before enrollment or who did not receive antipsychotics within one week, and the course of disease was less than 6 months; 5. All patients without any infection or autoimmune disease within two weeks; 6. Subjects who have been educated for more than 6 years; 7. Subjects with IQ >= 70; 8. Han population.
Exclusion criteria
Exclusion criteria: 1. Non schizophrenic patients with other mental diseases (determined by SCID); 2. Patients with severe or unstable diseases, or severe inflammatory or immune diseases, including heart disease, epilepsy, liver and kidney disease, diabetes, aplastic anemia, systemic lupus erythematosus or asthma; 3. Patients who used anti-inflammatory drugs (such as celecoxib, p-lactam antibiotics), hormones or immunosuppressants within 6 months before entering the study; 4. Patients with contraindications of celecoxib treatment; 5. Women of childbearing age who have planned pregnancy, pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PANSS;indoleamine2,3-dioxygenase;tumor necrosis factor a;interleukin 1ß;interleukin 4;interleukin 6;interleukin 17;Interferon ?; | — |
Countries
China
Contacts
Public ContactLuxian Lyu
The Second Affiliated Hospital of Xinxiang Medical College
Outcome results
None listed