Intracranial Lesions
Conditions
Interventions
Group A:Intravenous injection of dexamethasone (1 ug / kg)
Group B:DEX1ug/kg mixed with ropivacaine perineural
Sponsors
Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Preoperative diagnosis of intracranial space occupying or intracranial vascular disease was clear, and craniotomy was performed; 2. ASA grade I - III, no serious cardiopulmonary system and mental disease; 3. The subjects had informed consent to the study, and the degree of cooperation was good.
Exclusion criteria
Exclusion criteria: 1. The incision was beyond the block area; The operation time was more than 6 hours; 2. Before operation, there were obvious abnormalities of heart, liver and kidney function, serious electrolyte disorder and obvious organic diseases; 3. Bradycardia and heart block; 4. History of allergy to any research drug and narcotic drug, history of chronic pain, long-term use of opioids or benzodiazepines; 5. Patients with preoperative disturbance of consciousness and unable to communicate normally, patients with postoperative cognitive dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure;heart rate;Serum cortisol level;dosage of Intraoperative opioid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative anesthetic dosage;Postoperative analgesic dosage;Postoperative adverse reactions; | — |
Countries
China
Contacts
Public ContactChen Chen
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed