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Research on the clinical efficacy and mechanism of Liraglutide in glucocorticoid-induced hyperglycemia

Research on the clinical efficacy and mechanism of Liraglutide in glucocorticoid-induced hyperglycemia

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000041308
Enrollment
Unknown
Registered
2020-12-23
Start date
2020-09-01
Completion date
Unknown
Last updated
2021-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperglycemia

Interventions

Sponsors

Affiliated Hospital of Guizhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. In the screening period, the subjects are not limited to gender, aged between 18 and 80 years. 2. The patients who had been diagnosed with diabetes mellitus had higher blood glucose, which met who 1999 diabetes diagnostic criteria. 3. Patients who were treated with prednisone acetate >= 5mg / D or methylprednisolone >= 4mg / D at the time of enrollment had been treated for more than 1 month and would continue to use for more than 16 weeks. 4. Subjects with blood glucose >= 12 mmol / L at least twice within 24 hours were randomly selected. 5. Subjects with BMI >= 20.0kg/m2. 6. Subjects who can and are willing to provide written informed consent and comply with the requirements of this study.

Exclusion criteria

Exclusion criteria: 1. Pregnant women or women planning to get pregnant during the study period, women in lactation period or women with fertility without effective and medically approved contraceptive methods. 2. Patients with type 1 diabetes or diabetic ketoacidosis. 3. Patients with a history of medullary thyroid carcinoma or family history and type 2 multiple endocrine neoplasia syndrome. 4. Patients with congestive heart failure classified as grade IV by the New York Heart Association (NYHA). 5. Patients with inflammatory bowel disease and diabetic gastroparesis. 6. 73 M2 (Cockcroft Gault formula). 7. Patients with severe liver damage. 8. Patients participating in other clinical trials; 9. Subjects considered unsuitable for clinical trials for other reasons.

Design outcomes

Primary

MeasureTime frame
c-peptide;pancreatic glucagon;interleukin-6;Hypersensitive C-reactive protein;body composition;

Countries

China

Contacts

Public ContactZhang Miao

Affiliated Hospital of Guizhou Medical University

20057544@qq.com+86 13595008067

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026