Hemophilia
Conditions
Interventions
experimental group:tranexamic acid to control bleeding after ultrasonic scaling
control group:concentrate factor VIII to control bleeding after ultrasonic scaling
Sponsors
Peking Union Medical College Hospital (PUMCH) China Academy of Medical Science (CAMS)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: (1) Patients with severe hemophilia A or B were included in this study; (2) Aged >=12 years; (3) platelet count > 20 x 10^9; (4) Able to read and write, able to complete the questionnaire independently; (5) Different teeth on both sides of the mouth < 3; (6) Patients with dental calculus, gingivitis and early periodontal disease should be cleaned and treated; (7) The informed consent of the patient is willing to participate in dental cleaning treatment.
Exclusion criteria
Exclusion criteria: (1) Patients receiving continuous clotting factor prophylaxis treatment; (2) Patients with corresponding coagulation factor inhibitors; (3) Patients with allergy to tranexamic acid were excluded from the bypass hemostatic drug group; (4) Patients with acute hematuria attack or renal insufficiency were excluded in the bypass hemostatic drugs group; (5) Patients unable to participate in the study due to major diseases; (6) Patients who had taken aspirin or non-steroidal anti-inflammatory drugs within the last week; (7) HIV-infected patients; (8) Patients with active hepatitis or cirrhosis; (9) Three different > teeth on both sides of the mouth; (10) Patients unwilling to fill in the questionnaire or accept oral examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the bleeding time after ultrasonic scaling; | — |
Countries
China
Contacts
Public ContactKuixing Li
Peking Union Medical College Hospital (PUMCH) China Academy of Medical Science (CAMS) & Peking Union Medical College (PUMC)
Outcome results
None listed