Sleep disorder
Conditions
Interventions
experimental group:Goal-directed sedation with Ramazolam
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1.Aged >= 65 years; 2.Scheduled to undergo total hip replacement, femoral head replacement or total knee arthroplasty under intravertebral anesthesia; 3.Agreement of participating in the study and informed consent being signed.
Exclusion criteria
Exclusion criteria: 1.Being allergic to benzodiazepines or dexmedetomidine; 2.Requring for hypnotic every night within one month before surgery; 3.Serious hepatic dysfunction (in Child-Pugh grade C level); 4.Serious renal dysfunction (requiring for dialysis); 5.Known sick sinus syndrome, severe sinus bradycardia ( < 50 beats per min [bpm]), or second degree or more severe atrioventricular block without pacemaker; 6.Hypotension (SBP < 90 mmHg, MAP < 70 mmHg or SBP is more than 30% lower than base value) or anticipated survival time < 24 h; 7.ASA grade of IV and above; 8.Other conditions that researchers consider it inappropriate to be included in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep quality of postoperative night; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality of postoperative night and 1-2 days after surgery;Pain score of 1-3 days after surgery;nausea and vomiting of 1-3 days after surgery;The length of hospitalization after surgery;Complications and survival within 30 days after operation; | — |
Countries
China
Contacts
Public ContactMeng Zhaoting
Peking University First Hospital
Outcome results
None listed