Mild cognitive impairment
Conditions
Interventions
control group:health education
Sponsors
Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) It accords with the diagnostic criteria of amnesia mild cognitive impairment; (2) Aged 55 to 75 years; (3) The chief complaint includes subjective sensory memory loss; (4) Objective examination showed memory loss and cognitive changes: the MoCA score was less than 26 (180.25). If the length of education was less than 12 years, the score would be added to the score of; MMSE (24,29). The AVLT score was below 1.5 standard deviations of age and education (55-59 <= 4, 60-69 <= 3, 70-75 <= 2); (5) The (CDR) score of the Clinical dementia rating scale was 0.5 or the (GDS) score of the Comprehensive decline scale was 2 or 3, which did not meet the diagnostic criteria of dementia in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders revised version IV (DSM-IV-R); (6) Activities of daily living scale (ADL) evaluation of activities of daily living is basically normal, independent living function is complete; (7) Did not take drugs to improve mental or motor disorders; (8) The subjects are primary school grade 6 or above, have the ability to complete the cognitive ability test and other tests stipulated in the program, and have the ability and time to complete the prescribed aerobics training; (9) Did not engage in regular exercise in the past three months (that is, at least 3 times a week, each time at least 20 minutes of various forms of regular exercise); (10) The subjects informed consent and volunteered to participate.
Exclusion criteria
Exclusion criteria: (1) The Hachinsk ischemia index scale (HIS) score was > 4; (2) Other causes of cognitive decline: cerebrovascular disease, central nervous system infection, g - disease, huntington's chorea, DLB and Parkinson's disease, traumatic brain dementia, other physical and chemical factors (such as drugs, alcohol, CO), important body disease (hepatic encephalopathy, pulmonary encephalopathy), intracranial space-occupying lesions (a subdural hematoma, brain tumor), the endocrine system lesion (thyroid disease, parathyroid disease), and vitamins or other cognitive causes of dementia; (3) A history of neurological diseases (including stroke, optic neuromyelitis, epilepsy, Parkinson's disease, etc.); (4) Psychiatric patients, dSM-IV criteria for schizophrenia or other psychiatric disorders, bipolar affective disorder, major depression or delirium; (Hamilton anxiety scale (HAMA) assessment, scoring > 6; Hamilton depression scale (HAMD) had 21 evaluations, scoring > 8 points. (5) Abnormal laboratory indicators: liver function (ALT or AST) is 1.5 times higher than the upper limit of the normal range; Cr is 1.5 times higher than the upper limit of the normal range; anemia is moderate or above; fasting blood glucose value is 1.5 times higher than the upper limit of the normal range; (6) Unstable or severe heart, lung, liver, kidney, hematopoietic diseases; Severe diseases with poor prognosis, such as malignant tumors, have been informed; (7) The presence of uncorrectable visual and auditory disorders can not complete the scale and other relevant tests; (8) A history of serious alcohol and drug abuse within two years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment Scale;Hemoglobin content; | — |
Secondary
| Measure | Time frame |
|---|---|
| Auditory Verb Learning test;mini-mental state examination; | — |
Countries
China
Contacts
Public ContactGuo Yi
Tianjin University of Traditional Chinese Medicine
Outcome results
None listed