Gastrointestinal disease
Conditions
Interventions
Propofol group:Propofol intravenous induction and maintenance
remazolam group:Remazolam intravenous induction and maintenance
Sponsors
Renmin Hospital of Wuhan University
Eligibility
Sex/Gender
Male
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 65-80 years, no gender limit; 2. Patients undergoing laparoscopic gastrointestinal surgery (such as radical resection of gastric and colorectal cancer, etc.) under general anesthesia; 3. ASA classification I-III; 4. 18kg/m2 <= BMI <= 30 kg/m2; 5. Able to understand the research process and the use of cognitive scales, and be able to communicate effectively with researchers; 6. Volunteer to participate and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those who have participated in other drug clinical trials in the past 3 months; 2. Those with incomplete clinical examination data and those who think it is inappropriate to participate in this experiment; 3. People with communication disorders (language disorders, mental disorders); 4. People with cardiovascular diseases such as severe atrioventricular block and severe cardiac insufficiency; 5. People who are known to be intolerant or allergic to the experimental drugs used in this study; 6. Accompanied by peripheral vascular disease, sleep disorders, and recent use of antidepressants and hypnotics; 7. Have a history of neurological diseases: history of head injury, intracranial hypertension, cerebral aneurysm, cerebrovascular accident.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ratio of Perioperative neurocognitive disorders; | — |
Secondary
| Measure | Time frame |
|---|---|
| nausea and vomiting;Sleep quality;Incidence of injection pain;Incidence of dizziness;Serum neuron injury factors level;Serum inflammatory factors level;Patient satisfaction score for anesthesia; | — |
Countries
China
Contacts
Public ContactXia Zhongyuan
Renmin Hospital of Wuhan University
Outcome results
None listed