elective surgery of heart valve, coronary artery bypass, large vessel, or surgery for children with complicated congenital heart disease
Conditions
Interventions
bicarbonate ringer's:Sodium bicarbonate ringer's
lactate ringer's:lactate ringer's
Sponsors
The People's Hospital of Gaozhou
Eligibility
Sex/Gender
All
Age
No minimum to 90 Years
Inclusion criteria
Inclusion criteria: 1. Elective surgery of heart valve , coronary artery bypass, large vessel, or surgery for children with complicated congenital heart disease; 2. Cardiopulmonary bypass duration over 90min.
Exclusion criteria
Exclusion criteria: 1. Possible brain damage; 2. Patients after cardiopulmonary resuscitation; 3. Patients with a history of hypermagnesemia or hypothyroidism; 4. Pregnant or breastfeeding; 5. Patients whose death is considered inevitable; 6. Other situations that researcher believes are not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| standard base excess (BE) at 24h;proportion of patients with creatinine concentration>25% at 24h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum lactate, HCO3-, BE, lactate clearance, ScvO2, CO2 gap from preoperative to 24h of surgery;change of serum electrolytes from preoperative to 24h of surgery;change of platelet, Hb count from preoperative to 24h of surgery;proportion and duration of renal replacement therapy (RRT) use;ICU mechanical ventilation utilization rate and duration;ICU vasoactive drugs use, amount and duration;total amount of blood products use from preoperative to 24h of surgery;total amount of crystaloid solution use from preoperative to 24h of surgery;ICU length of stay;Drug-related adverse events (AE) within 24 hours postoperative, including but not limited to the incidence of electrolyte disturbances during ICU; | — |
Countries
China
Contacts
Public ContactMinghai Xian
The People's Hospital of Gaozhou
Outcome results
None listed