threatened miscarriage
Conditions
Interventions
Threatened miscarriage group:No need
Normal pregnancy group:No need
Sponsors
The First Affiliated Hospital of Guangzhou Traditional Chinese Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for normal pregnancies are: (1) aged 18–45 years; (2)the menopause time is 4-8 weeks; (3)blood ß-hCG is positive, and the blood ß-hCG level is consistent with the gestational age; (4)Ultrasonography indicates normal intrauterine pregnancy and matches gestational ages; (5)no abortion symptoms such as vaginal bleeding or abdominal pain. The above (1) to (5) are required. Inclusion criteria for threatened abortion are: (1) aged 18–45 years; (2)the menopause time is 4-8 weeks; (3)blood ß-hCG is positive; (4)level of ß-HCG is not consistent with gestational ages; (5) vaginal bleeding with closed cervical os or abdominal pain; (6)Ultrasonography suggestes endometrial cavity fluid; (7)Ultrasonography suggestes weak embryonic heartbeat. The above (1) (2) (3) is a necessary condition, (4) ~ (7) meets one or more.
Exclusion criteria
Exclusion criteria: (1)Chromosomal abnormalities in either or both spouses; (2)Suffering from endocrine diseases,or autoimmune diseases,or infectious diseases, or inflammatory diseases of the gastrointestinal tract; or inflammatory diseases of the reproductive tract;or systemic inflammatory disease; or serious diseases of vital organs such as brain, liver, kidney, blood system, etc; or diagnosed with anxiety and depression; or anorexia nervosa; or with mental disorders and unable to cooperate; (3)Taking antibiotics or antifungal drugs or drugs that impair embryonic development or enema within 3 months; (4)sexual life, vaginal or cervical topical medication, or vaginal irrigation within 48 hours; (5)IUD placement status; (6)still in the last pregnancy and lactation period; (7)with excessive vaginal bleeding, which may affect the quality of the sample; (8)refuse to be followed up; (9)refuse to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ultrasound;serum hCG;serum progesterone;serum estradiol; | — |
Secondary
| Measure | Time frame |
|---|---|
| ph (vaginal secretion);leucocyte esterase (vaginal secretion);Vaginal discharge hydrogen peroxide;Vaginal secretions sialidase;Vaginal secretions beta-glucuronidase;Vaginal secretions Acetylglucosaminidase; | — |
Countries
China
Contacts
Public ContactJie Gao
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed