Cerebral microvascular disease complicated with cognitive dysfunction
Conditions
Interventions
Cognitive impairment group:Nil
Sponsors
Lianyungang Second People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The patients who received MRI scan and showed lacunar infarction (LI), lacunar infarction (lacune), white matter lesions (WML), perivascular space enlargement and cerebral microbleeds (CMB) in imaging, and met the clinical diagnostic requirements of 2014 edition of "expert consensus on the diagnosis and treatment of cerebral small vessel disease".
Exclusion criteria
Exclusion criteria: 1. Subjects with obvious blindness, deafness and speech difficulty; 2. Patients diagnosed with schizophrenia, affective disorder, organic mental disorder and mental retardation; 3. Patients with dementia syndrome in degenerative diseases (Parkinson's disease, diffuse Lewy body disease, chronic progressive chorea, progressive supranuclear paralysis, thalamic dementia, Creutzfeldt Jakob disease); 4. Patients with pseudodementia (depression, delirium, brain abscess, brain tumor, hypothyroidism, hypopituitarism, vitamin deficiency, chronic renal failure and hepatic encephalopathy, etc.); 5. Subjects with normal cognitive function who have taken cholinesterase inhibitors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clock-related genes Per1 and Cry1; | — |
Countries
China
Contacts
Public ContactXiaozhu Shen
Lianyungang Second People's Hospital
Outcome results
None listed