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Vessel flow void sign and hyperintense vessel sign on FLAIR are the key distinguishing characteristics between MELAS and AIS

Vessel flow void sign and hyperintense vessel sign on FLAIR are the key distinguishing characteristics between MELAS and AIS

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000041132
Enrollment
Unknown
Registered
2020-12-19
Start date
2020-12-18
Completion date
Unknown
Last updated
2021-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes

Interventions

Gold Standard:Muscle pathology shows typical ragged-red fibers
Gene sequence detects A3243G mutation.
Index test:MRI&#32
FLAIR&#32
images:&#32
vessel&#32
flow&#32
void&#32
sign&#32
and&#32
hyperintensive&#32
sign.

Sponsors

Nanfang Hospital of Southern Medical University
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: Patients exactly diagnosed with MEALS or AIS.

Exclusion criteria

Exclusion criteria: MRI examination lacks MRA and ASL sequence.

Design outcomes

Primary

MeasureTime frame
vessel flow void sign;Hyperintensive vessel sign;SEN, SPE, ACC, AUC of ROC;—

Countries

China

Contacts

Public ContactHaishan Jiang

Nanfang Hospital of Southern Medical University

jianghs@smu.edu.cn+86 18665604153

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026