The effects of pretreatment with single low dose esketamine on the pharmacodynamics of propofol and cisatracurium during anesthesia induction

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000041041

Enrollment

Unknown

Registered

2020-12-16

Start date

2020-12-10

Completion date

Unknown

Last updated

2023-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

the pharmacodynamics of propofol and cisatracurium during anesthesia induction

Interventions

Group A:Pretreatment with 0.1mg/kg ketamine

Group B:Pretreatment with 0.3mg/kg ketamine

Group C:Pretreatment with 0.5mg/kg ketamine

Group D:Pretreatment with 0.5ml/kg saline

Eligibility

Sex/Gender

All

Age

19 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. ASA physical status I or II; 2. Patients aged 19~75 years.

Exclusion criteria

Exclusion criteria: 1. A history of anaesthetic allergy; 2. Patients with severe liver, kidney, hematopoiesis and other diseases; 3. Neuromuscular conduction disorders; 4. Pregnant women; 5. Drugs that interact with neuromuscular blockers; 6. Patients expecting difficult airway; 7. Patients with contraindications to ketamine; 8. Long term use of calcium antagonists and antidepressants in patients.

Design outcomes

Primary

Measure	Time frame
Propofol dosage during anesthesia induction;Onset time of cisatracurium;The lowest BIS during induction;	—

Secondary

Measure	Time frame
Heart rate immediately after anesthesia induction;Mean arterial pressure immediately after anesthesia induction;	—

Countries

China

Contacts

Public ContactLonghui Cao

Sun Yat-Sen University Cancer Center

caolh@sysucc.org.cn+86 13826092036

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 5, 2026