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Combined detection of multiple gene mutations in human circulating tumor DNA

Combined detection of multiple gene mutations in human circulating tumor DNA

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000041034
Enrollment
Unknown
Registered
2020-12-16
Start date
2020-12-18
Completion date
Unknown
Last updated
2021-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

non-small cell lung cancer

Interventions

Gold Standard:digital PCR
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Sponsors

Beijing Chest Hospital affiliated to Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: (1) Over 18 years of age; (2) One of the following can be satisfied: 1) Diagnosed with non-small cell lung cancer (NSCLC) in middle-late stage (i.e. the pathological staging of III ~ IV) patients; 2) Interference group samples clinically diagnosed as pulmonary benign tumor, small cell lung cancer, etc.; (3) 14-20ml peripheral blood samples can be collected, and corresponding samples should be provided for patients undergoing homology study FFPE samples;(Synchronous definition: for the surgical tissue, blood collection is required within one week before the operation; for the puncture tissue, the time difference between the collection of tissue and peripheral blood is required within one week). (4) Sign informed consent voluntarily.

Exclusion criteria

Exclusion criteria: (1) Patients with unqualified quality control of nucleic acid samples after extraction; (2) patients diagnosed with the second primary malignant tumor; (3) Patients who have received previous transplantation operations; (4) Patients who have received allogeneic blood transfusion or immunotherapy that may introduce foreign DNA or other patients who may introduce foreign DNA within one year; (5) Poor compliance or conditions that the researcher considers inappropriate to be included in the study; (6) Incomplete samples of case information.

Design outcomes

Primary

MeasureTime frame
gene mutation;Consistency;

Countries

China

Contacts

Public ContactChe Nanying

Beijing Chest Hospital affiliated to Capital Medical University

cheny0448@163.com+86 10-89509381

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026