minimal hepatic encephalopathy
Conditions
Interventions
Probiotic group:3 bid capsules of Bifidobacterium Triple Live bacteria
Rifaximin group:Rifaximin0.6g, bid
Lactulose group:Lactulose (Adjust freely according to the number of stools)
Sponsors
Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. The patient or his or her family (guardian) agrees to participate in this study and sign the informed consent form. 2. The age is from 30 to 70 years old, regardless of sex. 3. She was clinically diagnosed as liver cirrhosis and diagnosed as MHE by PHES score. 4. The condition was stable within 3 months, and there were no obvious complications of liver cirrhosis. 5. Patients are willing to accept late follow-up and other agreement requirements.
Exclusion criteria
Exclusion criteria: 1. Patients who have a pregnancy plan during pregnancy or during the trial. 2. Patients who have any doubts about the technology or have a history of other risks. 3. Patients at the end of the disease or who may die in the study. 4. Study of patients who participated in other clinical trials three months before enrollment. 5. Patients who had participated in any other flora treatment before they were enrolled in the study. 6. There are symptoms of gastrointestinal bleeding such as hematemesis and black stool or other serious complications of liver cirrhosis in the past 1 month. 7. Patients with severe cardiopulmonary, liver and renal insufficiency. 8. Had obvious history of HE or HE and had undergone transjugular intrahepatic portosystemic shunt. 9. Recently used antibiotics, lactulose, LOLA, branched chain amino acids, yogurt and probiotics. 10. Any patients who are considered by the researchers to be unable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal 16s gene sequencing;ammonia;Child;HRQOL; | — |
Secondary
| Measure | Time frame |
|---|---|
| Endotoxin; | — |
Countries
China
Contacts
Public ContactXi Chen
Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University
Outcome results
None listed