Helicobacter pylori infection
Conditions
Interventions
a:Vonolasheng 20 mg 2/day + Amoxicillin 750 mg 4/day for 7 days
b:Vonoprazan 20mg 2/day + Amoxicillin 500mg 4/day for 7 days
c:Vonoprazan 20mg+ Amoxicillin 750mg+ Clarithromycin 500mg, twice a day for 7 days
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age ranging from 18 to 70 years; (2) chronic gastritis with or without healed duodenal or stomach ulcer; (3) H. pylori (+) determined by C13 or C14 (4) treatment-naive patients for eradication of H. pylori infection.
Exclusion criteria
Exclusion criteria: (1) Allergy to medications used in this clinical trial; (2) Use of PPI, histamine H2-receptor antagonists, antibiotics, bismuth, or probiotics 4 weeks before initiating study treatment; (3) Use of adrenocorticosteroids, nonsteroidal anti-inflammatory drugs, and anticoagulants; (4) Alcohol abuse; (5) Presence of diseases or clinical conditions, such as liver disease, cardiac vascular disease,lung disease, kidney disease, metabolic disease, mental illness, or malignant tumors, that might interfere with the evaluation of study treatment; (6) Female patients planning pregnancy, as well as pregnant and breastfeeding patients; (7) Previous esophageal or stomach surgical procedures; (8) Participation in other clinical studies within 3 months before enrollment in this clinical study; (9) Incomplete follow-up or noncompliance with the study treatment; (10) Patients who cannot sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 13C-Urea Breath Test;14C-Urea Breath Test; | — |
Countries
China
Contacts
Public ContactDe-Kui Zhang
Lanzhou University Second Hospital
Outcome results
None listed