Acute posterior circulation large vessel occlusion
Conditions
Interventions
EVT combined with SMT group:EVT combined with SMT
standard medicine treatment group:SMT
Sponsors
The Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Preliminarily judged as posterior circulation ischemic stroke based on clinical symptoms or imaging examination; 2) Posterior circulation aorta occlusion confirmed by CTA/MRA/DSA (basal artery and isolated vertebral artery V4 segment); 3) Aged 18-80 years; 4) The time from onset to randomization is within 24 hours; 5) NIHSS score >= 10 points; 6) PC-ASPECT score >= 6 points; 7) Patient or family members sign informed consent.
Exclusion criteria
Exclusion criteria: 1) Cerebral CT or MRI confirmed intracranial hemorrhage; 2) mRS score >= 3 points before the onset; 3) Pregnant or breastfeeding women; 4) Allergy to contrast agents or nickel-titanium alloy; 5) Participating in other clinical trials; 6) Contraction Pressure> 185 mmHg or diastolic blood pressure> 110 mmHg, and oral antihypertensive drugs cannot be controlled; 7) Genetics or acquired hemorrhage, lack of anticoagulant factors; or oral anticoagulants and INR>1.7; 8) Blood glucose 400 mg/dl (22.2 mmol/L), platelets <100*10^9/L, or hematocrit <25%; 9) The artery is tortuous until the thrombus removal device cannot reach the target blood vessel; 10) Hemorrhage history in the past 6 months; 11) Life expectancy <1 year; 12) Expected failure to complete follow-up; 13) Obvious mass effect or hydrocephalus in the cerebellar hemisphere on imaging; 14) Bilateral brain on imaging Diffuse ischemic manifestations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mRS in 0-3 score at 90 days;The incidence of symptomatic intracranial hemorrhage within 48 hours and the 90-day mortality rate.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in NIHSS score 5-7 days after operation;Changes in NIHSS score 24h after operation;Incidence of complications of non-intracranial hemorrhage;Operation and device-related complications.; | — |
Countries
China
Contacts
Public ContactQingwu Yang
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed