Thoracoscopic thoracic surgery
Conditions
Interventions
High-dose esketamine group:After induction of anesthesia, continuous intravenous infusion of 0.25 mg / kg / h of esketmine was performed until chest closure began
control group:normal saline
Low-dose esketamine group:After induction of anesthesia, continuous intravenous infusion of 0.15mg / kg / h of esketmine was performed until chest closure began
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years; 2. ASA grade I - II; 3. BMI 18.5-30; 4. Thoracoscopic lung surgery under general anesthesia; 5. Patients with postoperative patient-controlled intravenous analgesia pump (PCIA) treatment; 6. Patients or family members have a full understanding of the purpose and significance of this trial, and voluntarily participate in the clinical trial, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Chronic pain or opioid use before operation; 2. Drug allergy needed in this study; 3. Those who have mental illness and can't cooperate; 4. Inability to communicate due to cognitive impairment or language impairment before surgery; 5. Abnormal function of heart, liver and kidney; 6. Those who have mental illness and can't cooperate; 7. Blood pressure greater than or equal to 180 / 100mmhg; hypertension without treatment or poor control; 8. Glaucoma, intracranial hypertension, hyperthyroidism; 9. Alcoholics; 10. Other situations in which the investigator judged that the patient was not suitable to participate in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Opioid consumption of perioperative patients;Recovery time of general anesthesia;Choking and restlessness during recovery;Recovery period delirium;The rest NRS scores after extubation and after operation: 1 h, 2 h, 4 h, 8 h, 12 h, 24 h, 48 h rest NRS scores;After extubation and postoperative exercise NRS score: 4h, 8h, 12h, 24h, 48h; | — |
Secondary
| Measure | Time frame |
|---|---|
| The time of the first analgesia and the times of additional analgesia after operation, and the dosage of drugs;The time of first exhaust, eating and getting out of bed were observed;Satisfaction score of patients with postoperative analgesia at 24 and 48 hours after operation;Sedation score, nausea and vomiting score and medication condition at 24 and 48 hours after operation;Postoperative hallucinations, nightmares, headache, drowsiness, pruritus, irritability, catheter irritation, respiratory depression, etc;Anxiety, depression and sleep were observed 24, 48 h, 1 W, 1 month and 3 months after operation; | — |
Countries
China
Contacts
Public ContactJingjing Yuan
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed