diabetic complications
Conditions
Interventions
Diabetes group:nothing
Diabetic peripheral neuropathy group:Nil
Diabetic foot group:Nil
Sponsors
Teaching Hospital of Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: (1) the subjects voluntarily participate in the clinical trial and signe the written informed consent; (2) the subjects can understand the oral and / or written instructions and comply with all experimental requirements; (3) the subjects are male or female aged 18-70 years old; (4) they meet the clinical manifestations of diabetes and complications (diabetic nephropathy, diabetic peripheral neuropathy, diabetic foot disease, etc.) Performance and diagnostic criteria. Inclusion criteria of healthy volunteers: (1) subjects voluntarily participate in the clinical trial and signe written informed consent; (2) subjects can understand oral and / or written instructions and comply with all experimental requirements; (3) subjects are male or female aged 18-70 years old; (4) healthy people without diabetes history.
Exclusion criteria
Exclusion criteria: (1) patients with malignant tumors, autoimmune diseases, infectious diseases and renal insufficiency who underwent gastrointestinal surgery in the past year; (2) patients with acute metabolic disorders such as diabetic ketoacidosis in the past month; (3) pregnant and lactating women; (4) patients with severe infection in the past month; (5) alcoholism or drug abuse; (6) patients who are receiving hormone or chemotherapy and have used antibiotics within one month; (7) patients with unconsciousness, dementia and various mental diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 16S rRNA sequencing analysis of intestinal microorganisms;Metagenomics sequencing analysis of intestinal microflora;Non targeted metabonomics based on LC-MS;Lipidomics;Short chain fatty acids; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine examination;blood sugar;insulin;glycosylated hemoglobin;Tumor necrosis factor-a;Interleukin-1 ß;Interleukin-6;Plantar thermal response time;Sciatic nerve conduction velocity;24h urinary albumin;Serum creatinine;Serum urea nitrogen;Stromal cell derived factor-1;Hypoxia inducible factor-1 a; | — |
Countries
China
Contacts
Public ContactQiyue Yang
Teaching Hospital of Chengdu University of Traditional Chinese Medicine
Outcome results
None listed