PA-HSOS
Conditions
Interventions
Gold Standard:Original Nanjing Index: 1. A definite history of PA intake
2. Abdominal distention and/or hepatomegaly, liver pain, ascites
3. Abnormal liver function test
4. Typical characteristics of enhanced CT or MRI. 5.Pathologically confirmed diagnosis includes swelling, damage and shedding of hepatic sinusoidal endothelial cells 
Index test:1. 
of 
alkaloid 
protein 
and 
serum 
adduct)
 
2. 
Sponsors
The Affiliated Drum Tower Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) Symptoms: including abdominal distension, jaundice, anorexia, oliguria, etc., with or without a history of pyrrole alkaloids medication; 2) Abnormal liver function (ALT > 40u/L, AST > 40u/L, or TB > 34umol/L); 3) Informed consent.
Exclusion criteria
Exclusion criteria: 1. There are contraindications for CT or MRI examination (such as renal insufficiency), which can not be evaluated by Nanjing standard; 2. There are many chronic liver damage factors (such as hepatophilic virus infection, long-term drinking history, cholestasis, autoimmune, etc.) in the past; 3. Participants in other clinical trials at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SEN, APE, ACC, AUC of ROC ; | — |
Countries
China
Contacts
Public ContactZhuge Yuzheng
The Affiliated Drum Tower Hospital of Nanjing University Medical School
Outcome results
None listed