Helicobacter pylori infecion
Conditions
Interventions
A:minocycline (100mg twice a day) +clarithromycin(500mg,twice a day)+ bismuth(220mg,twice a day)+esomeprazole(20mg, twice a day) for two weeks
B:minocycline (100mg twice a day)+levofloxacin(500mg,twice a day)+ bismuth(220mg,twice a day)+esomeprazole(20mg, twice a day) for two weeks
C:clarithromycin (500mg twice a day) +axoxicillin(500mg,twice a day)+ bismuth(220mg,twice a day)+esomeprazole(20mg, twice a day) for two weeks
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients, aged between 18-70 years. 2. Patients who did not take antibiotics, bismuth and traditional Chinese medicine 4 weeks before treatment, and patients who took PPI, H2 receptor antagonists and other drugs that affect HP activity 2 weeks before treatment; 3. Patients who were diagnosed as HP positive by C13 or C14 urea breath test, rapid urease test and histopathology, and who had not received HP eradication treatment before; 4. Informed and agreed to participate in the study, patients with complete medical records and follow-up records.
Exclusion criteria
Exclusion criteria: 1. With severe heart, lung, and kidney dysfunction and low immunity; 2. Patients with drug allergy contraindications; 3. Persons with mental illness or communication difficulties; 4. Pregnancy, lactation; 5. Patients with organic diseases such as gastrointestinal tumor and gastrointestinal hemorrhage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse reaction;antibiotic resistance of Helicobacter pylori; | — |
Countries
China
Contacts
Public ContactZhihui Lin
Fujian Provincial Hospital
Outcome results
None listed