No specific target disease
Conditions
Interventions
Placebo-controlled group:received whole milk powder for 30 days
probiotic group:consumed a sachet of probiotic powder per day, containing 3.5×10^10 Lactobacillus plantarum P9
Sponsors
Affiliated Hospital of Inner Mongolia Medical University
Eligibility
Sex/Gender
All
Age
35 Years to 70 Years
Inclusion criteria
Inclusion criteria: Only when subjects meet all the following criteria are they suitable for inclusion in this study 1. Aged 35-70 years, no gender limit; 2. People who have been exposed to pesticides for a long time (exposure to pesticides more than or equal to twice a week); 3. Those who have not taken antibiotics in the past three months; If any of the above answers is "No", it cannot be included in clinical research.
Exclusion criteria
Exclusion criteria: If the subject meets any of the following criteria, it cannot be selected: 1. Those who have taken antibiotics in the past three months; 2. Patients with abnormal liver and kidney function; 3. People with a history of alcoholism; 4. People with a history of allergies to lactic acid bacteria and their products or with high allergies; 5. Those who have received other drug research within 3 months before screening; 6. The researcher believes that it is not suitable to participate in this research; 7. Poor blood pressure control (blood pressure >= 160mmHg/100 mmHg); 8. Those with active peptic ulcer; 9. People with previous intestinal diseases such as lactose intolerance, irritable bowel syndrome, inflammatory bowel disease, habitual diarrhea, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pesticide metabolite content in urine;Liver and kidney functional protein content, such as urine protein, alanine aminotransferase, aspartate aminotransferase;Metagenomics to determine the composition and metabolic changes of intestinal microbes;Determination of Serum Non-targeted Metabolism by High Performance Liquid Chromatography; | — |
Secondary
| Measure | Time frame |
|---|---|
| Elisa kit for determination of vitamins in blood;Determination of heavy metal content in blood, urine and feces with ink furnace atomic absorption spectrometer; | — |
Countries
China
Contacts
Public ContactZhao Jianmin
Outcome results
None listed