Effects of low-dose furosemide combined with aminophylline on renal function in septic shock patients

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000040822

Enrollment

Unknown

Registered

2020-12-11

Start date

2017-01-01

Completion date

Unknown

Last updated

2021-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

septic shock

Interventions

experimental group:low-dose furosemide combined with aminophylline

control groups:normal saline

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Admission icu diagnosis of septic shock patients. Diagnostic criteria for septic shock: 1.Clear infection foci; 2.There is systemic inflammatory reaction; 3.Systolic pressure below 90 mmhg or 40mmhg lower than the original base value, after active fluid resuscitation (20~40 ml/kg) blood pressure did not respond, or need vasoactive drugs to maintain; 4.Low perfusion with organ tissue, such as urine volume <30 ml/h, or acute disturbance of consciousness.

Exclusion criteria

Exclusion criteria: 1 Aged?18 years; 2.Pregnancy; 3 History of renal transplantation; 4 Renal artery stenosis; 5 Unilateral kidney; 6.Patients with a history of chronic kidney disease or glomerular filtration 40 kg/m2; 8.Patients with previous history of aminophylline or furosemide allergy;9.Patients with active peptic ulcer and uncontrolled convulsive disease.

Design outcomes

Primary

Measure	Time frame
Scr;BUN;CCR;GFR;urine volume;	—

Secondary

Measure	Time frame
HCT;ALB;CVP;	—

Countries

China

Contacts

Public ContactLiehua Deng

Department of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University

glinson@126.com+86 13809752886

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026