breast canner
Conditions
Interventions
trial group:Receive postoperative adjuvant chemotherapy
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
Female
Age
70 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Female, age >= 70 years old at admission, and expected survival time greater than 6 months; 2. Through hollow needle puncture or intraoperative and postoperative histopathological diagnosis of invasive breast cancer (excluding inflammatory breast cancer and intraductal cancer with suspicious or focal or micro-invasive); 3. Postoperative medical examination meets any one of the following: (1) Luminal B type (Ki-67 >= 30%); (2) HER-2 positive type; (3) Triple negative type; (4) Postoperative medical examination confirms the axillary Lymph node metastasis >=1 (not including micrometastasis and isolated tumor cells); 4. No other malignant tumors (except for controlled cervical carcinoma in situ and skin basal cell carcinoma); 5. Bone marrow function is normal, blood routine: neutrophils >= 2.5 x 10^9/L, hemoglobin >= 100g/L, platelets >= 100 x 10^9/L, no abnormal blood coagulation; 6. Normal liver and kidney function: AST = 55%; 8. ECOG score 0-1 points; 9. Willing to cooperate in postoperative chemotherapy and related treatment; 10. Sign the informed consent, and the compliance of the plan is good.
Exclusion criteria
Exclusion criteria: 1. Have previously used systemic or local treatments for breast cancer, including chemotherapy (except topical drugs); 2. Breast cancer has been found to have distant metastasis; 3. Those who cannot tolerate adjuvant chemotherapy and related treatments: those with uncontrolled lung diseases, severe infections, active peptic ulcers in need of treatment, coagulation dysfunction diseases, connective tissue diseases or bone marrow function suppression diseases; 4. Past congestive heart failure, uncontrolled or symptomatic angina, arrhythmia or myocardial infarction, uncontrollable hypertension (systolic blood pressure > 180mmHg or diastolic blood pressure > 100mmHg); 5. Those who are unwilling to undergo postoperative adjuvant chemotherapy; 6. Patients with mental illness or other reasons who cannot comply with treatment; 7. Those who are known to have a history of severe allergies to any of the drugs in the treatment plan; 8. Have used other chemotherapy drugs for breast cancer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frailty;quality of life;Nutritional status; | — |
Countries
China
Contacts
Public ContactChen Jie
West China Hospital of Sichuan University
Outcome results
None listed